Adolescent Literacy and Textbooks: An Annotated Bibliography

A companion report to Carnegie's Time to Act, provides an annotated bibliography of research on textbook design and reading comprehension for fourth through twelfth grade, arranged by topic. Calls for a dialogue between publishers and researchers

Executive stock option exercise with full and partial information on a drift change point

We analyse the optimal exercise of an executive stock option (ESO) written on a stock whose drift parameter falls to a lower value at a change point, an exponentially distributed random time independent of the Brownian motion driving the stock. Two agents, who do not trade the stock, have differing information on the change point, and seek to optimally exercise the option by maximising its discounted payoff under the physical measure. The first agent has full information, and observes the change point. The second agent has partial information and filters the change point from price observations. This scenario is designed to mimic the positions of two employees of varying seniority, a fully informed executive and a partially informed less senior employee, each of whom receives an ESO. The partial information scenario yields a model under the observation filtration $\widehat{\mathbb{F}}$ in which the stock drift becomes a diffusion driven by the innovations process, an $\widehat{\mathbb{F}}$-Brownian motion also driving the stock under $\widehat{\mathbb{F}}$, and the partial information optimal stopping value function has two spatial dimensions. We rigorously characterise the free boundary PDEs for both agents, establish shape and regularity properties of the associated optimal exercise boundaries, and prove the smooth pasting property in both information scenarios, exploiting some stochastic flow ideas to do so in the partial information case. We develop finite difference algorithms to numerically solve both agents' exercise and valuation problems and illustrate that the additional information of the fully informed agent can result in exercise patterns which exploit the information on the change point, lending credence to empirical studies which suggest that privileged information of bad news is a factor leading to early exercise of ESOs prior to poor stock price performance.Comment: 48 pages, final version, accepted for publication in SIAM Journal on Financial Mathematic

Terminated LDPC Convolutional Codes with Thresholds Close to Capacity

An ensemble of LDPC convolutional codes with parity-check matrices composed of permutation matrices is considered. The convergence of the iterative belief propagation based decoder for terminated convolutional codes in the ensemble is analyzed for binary-input output-symmetric memoryless channels using density evolution techniques. We observe that the structured irregularity in the Tanner graph of the codes leads to significantly better thresholds when compared to corresponding LDPC block codes.Comment: To appear in the proceedings of the 2005 IEEE International Symposium on Information Theory, Adelaide, Australia, September 4-9, 200

Impact of the selected boundary layer schemes and enhanced horizontal resolution on the Weather Research and Forecasting model performance on James Ross Island, Antarctic Peninsula

The output of the various Weather Research and Forecasting (WRF) model configurations was compared with ground-based observations in the northern part of James Ross Island, Antarctic Peninsula. In this region, a network of automatic weather stations deployed at ice-free sites (as well as small glaciers) is operated by the Czech Antarctic Research Programme. Data from these stations provide a unique opportunity to evaluate the WRF model in a complex terrain of James Ross Island. The model was forced by the ERA5 reanalysis data and the University of Bremen sea ice data. The model configurations include a novel Three-Dimensional Scale-Adaptive Turbulent Kinetic Energy (3D TKE) planetary boundary layer scheme and a more traditional Quasi-Normal Scale Elimination (QNSE) scheme. Impact of model horizontal resolution was evaluated by running simulations in both 700 m and 300 m. The validation period, 25 May 2019 to 12 June 2019, was selected to cover different stratification regimes of air temperature and a significant snowfall event. Air temperature was simulated well except for strong low-level inversions. These inversions occurred in 44% of all cases and contributed to a higher mean bias (2.0–2.9°C) at low-elevation sites than at high altitude sites (0.2–0.6°C). The selection of the 3D TKE scheme led to improvement at low-elevation sites; at high altitude sites, the differences between model configurations were rather small. The best performance in wind speed simulation was achieved with the combination of the 3D TKE scheme and 300 m model resolution. The most important improvement was decrease of bias at a coastal Mendel Station from 3.5 m·s‑1 with the QNSE scheme on the 700 m grid to 1.2 m·s‑1 with the 3D TKE scheme on the 300 m grid. The WRF model was also proven to simulate a large snowfall event with a good correspondence with the observed snow height

Design and Evaluation of a Collective IO Model for Loosely Coupled Petascale Programming

Loosely coupled programming is a powerful paradigm for rapidly creating higher-level applications from scientific programs on petascale systems, typically using scripting languages. This paradigm is a form of many-task computing (MTC) which focuses on the passing of data between programs as ordinary files rather than messages. While it has the significant benefits of decoupling producer and consumer and allowing existing application programs to be executed in parallel with no recoding, its typical implementation using shared file systems places a high performance burden on the overall system and on the user who will analyze and consume the downstream data. Previous efforts have achieved great speedups with loosely coupled programs, but have done so with careful manual tuning of all shared file system access. In this work, we evaluate a prototype collective IO model for file-based MTC. The model enables efficient and easy distribution of input data files to computing nodes and gathering of output results from them. It eliminates the need for such manual tuning and makes the programming of large-scale clusters using a loosely coupled model easier. Our approach, inspired by in-memory approaches to collective operations for parallel programming, builds on fast local file systems to provide high-speed local file caches for parallel scripts, uses a broadcast approach to handle distribution of common input data, and uses efficient scatter/gather and caching techniques for input and output. We describe the design of the prototype model, its implementation on the Blue Gene/P supercomputer, and present preliminary measurements of its performance on synthetic benchmarks and on a large-scale molecular dynamics application.Comment: IEEE Many-Task Computing on Grids and Supercomputers (MTAGS08) 200

Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications

Bioengineered spider silk is a biomaterial that has exquisite mechanical properties, biocompatibility, and biodegradability. Iron oxide nanoparticles can be applied for the detection and analysis of biomolecules, target drug delivery, as MRI contrast agents and as therapeutic agents for hyperthermia-based cancer treatments. In this study, we investigated three bioengineered silks, MS1, MS2 and EMS2, and their potential to form a composite material with magnetic iron oxide nanoparticles (IONPs). The presence of IONPs did not impede the self-assembly properties of MS1, MS2, and EMS2 silks, and spheres formed. The EMS2 spheres had the highest content of IONPs, and the presence of magnetite IONPs in these carriers was confirmed by several methods such as SEM, EDXS, SQUID, MIP-OES and zeta potential measurement. The interaction of EMS2 and IONPs did not modify the superparamagnetic properties of the IONPs, but it influenced the secondary structure of the spheres. The composite particles exhibited a more than two-fold higher loading efficiency for doxorubicin than the plain EMS2 spheres. For both the EMS2 and EMS2/IONP spheres, the drug revealed a pH-dependent release profile with advantageous kinetics for carriers made of the composite material. The composite spheres can be potentially applied for a combined cancer treatment via hyperthermia and drug delivery

Evaluation of the Importance of Time-Frequency Contributions to Speech Intelligibility in Noise

Recent studies on binary masking techniques make the assumption that each time-frequency (T-F) unit contributes an equal amount to the overall intelligibility of speech. The present study demonstrated that the importance of each T-F unit to speech intelligibility varies in accordance with speech content. Specifically, T-F units are categorized into two classes, speech-present T-F units and speech-absent T-F units. Results indicate that the importance of each speech-present T-F unit to speech intelligibility is highly related to the loudness of its target component, while the importance of each speech-absent T-F unit varies according to the loudness of its masker component. Two types of mask errors are also considered, which include miss and false alarm errors. Consistent with previous work, false alarm errors are shown to be more harmful to speech intelligibility than miss errors when the mixture signal-to-noise ratio (SNR) is below 0 dB. However, the relative importance between the two types of error is conditioned on the SNR level of the input speech signal. Based on these observations, a mask-based objective measure, the loudness weighted hit-false, is proposed for predicting speech intelligibility. The proposed objective measure shows significantly higher correlation with intelligibility compared to two existing mask-based objective measures

Plasmonic behavior of III-V semiconductors in far-infrared and terahertz range

Background: In this article, III-V semiconductors are proposed as materials for far-infrared and terahertz plasmonic applications. We suggest criteria to estimate appropriate spectral range for each material including tuning by fine doping and magnetic field. Methods: Several single-crystal wafer samples (n, p-doped GaAs, n-doped InP, and n, p-doped and undoped InSb) are characterized using reflectivity measurement and their optical properties are described using the Drude-Lorentz model, including magneto-optical anisotropy. Results: The optical parameters of III-V semiconductors are presented. Moreover, strong magnetic modulation of permittivity was demonstrated on the undoped InSb crystal wafer in the terahertz spectral range. Description of this effect is presented and the obtained parameters are compared with a Hall effect measurement. Conclusion: Analyzing the phonon/free carrier contribution to the permittivity of the samples shows their possible use as plasmonic materials; the surface plasmon properties of semiconductors in the THz range resemble those of noble metals in the visible and near infrared range and their properties are tunable by either doping or magnetic field.Web of Science13art. no. 1

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.

A sensitization of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca2+ release is associated with oxidative stress in multiple cell types. These effects are thought to be mediated by alterations in the redox state of critical thiols in the IP3R, but this has not been directly demonstrated in intact cells. Here, we utilized a combination of gel-shift assays with MPEG-maleimides and LC-MS/MS to monitor the redox state of recombinant IP3R1 expressed in HEK293 cells. We found that under basal conditions, ∼5 of the 60 cysteines are oxidized in IP3R1. Cell treatment with 50 μm thimerosal altered gel shifts, indicating oxidation of ∼20 cysteines. By contrast, the shifts induced by 0.5 mm H2O2 or other oxidants were much smaller. Monitoring of biotin-maleimide attachment to IP3R1 by LC-MS/MS with 71% coverage of the receptor sequence revealed modification of two cytosolic (Cys-292 and Cys-1415) and two intraluminal cysteines (Cys-2496 and Cys-2533) under basal conditions. The thimerosal treatment modified an additional eleven cysteines, but only three (Cys-206, Cys-767, and Cys-1459) were consistently oxidized in multiple experiments. H2O2 also oxidized Cys-206 and additionally oxidized two residues not modified by thimerosal (Cys-214 and Cys-1397). Potentiation of IP3R channel function by oxidants was measured with cysteine variants transfected into a HEK293 IP3R triple-knockout cell line, indicating that the functionally relevant redox-sensitive cysteines are predominantly clustered within the N-terminal suppressor domain of IP3R. To our knowledge, this study is the first that has used proteomic methods to assess the redox state of individual thiols in IP3R in intact cells. © 2018 Joseph et al

Interannual variability of air temperature inversions in ice-free area of northern James Ross Island, Antarctica

Air temperature inversions are common features in Antarctica, especially in the interior where they are observed nearly year-round. Large temporal variability of air temperature inversion incidence is typical for the coastal areas and little is known about its occurrence in the Antarctic deglaciated areas. Here we present a 12-year-long time series of near-surface air temperature inversion derived from two automatic weather stations situated at different altitudes (10 and 375 m a.s.l.) in ice-free part of northern James Ross Island (Antarctic Peninsula). The highest monthly relative frequency of temperature inversions during 2006–2017 was observed in July (38%) when the range between minimum and maximum monthly frequencies reached 34%. Both the lowest monthly relative frequency of temperature inversions and the range were found in December with values of 7% and 15%, respectively. The correlation between mean lapse rate and selected mesoscale flow characteristics were tested. The highest correlations were found between lapse rate and specific humidity for the yearly means (0.69 in the 925 hPa pressure level). Negative correlation coefficients were established between lapse rate and air temperature in summer (− 0.65 in the 500 hPa pressure level). Finally, we also used the Weather and Research Forecasting (WRF) model to ascertain its ability to simulate situations as complicated as near-surface air temperature inversion formation in complex terrain. For a strong winter air temperature inversion, simulated air temperature was compared with in situ observations to assess the model performance.publishedVersio